Delta 9 THC is the primary psychoactive component of cannabis, responsible for the “high” that marijuana users experience. When it comes to consuming THC, edibles are becoming an increasingly popular method. But how exactly do THC edibles work in the body? Let’s break down the science.
1. Ingestion
When you consume a THC edible, whether it’s a gummy, brownie, or any other food item infused with THC, it goes through the digestive system. Unlike smoking or vaping, where THC is rapidly absorbed into the bloodstream through the lungs, edibles take longer to take effect as they have to be metabolized by the liver.
2. Metabolism
Delta 9 THC is converted into 11-hydroxy-THC in the liver, which is a more potent form of THC. This process is known as first-pass metabolism. The liver breaks down THC into different metabolites, including 11-hydroxy-THC, which then circulates throughout the body.
3. Blood-Brain Barrier
11-hydroxy-THC crosses the blood-brain barrier, a protective membrane that prevents harmful substances from entering the brain. Once in the brain, THC and its metabolites bind to cannabinoid receptors, specifically CB1 receptors, which are part of the endocannabinoid system.
4. Effects
THC and its metabolites exert their effects by modulating neurotransmitter release, particularly dopamine and glutamate. This leads to the characteristic euphoria, relaxation, altered perception of time, and increased appetite associated with THC consumption.
5. Duration
The effects of THC edibles can last much longer compared to smoking or vaping, as the metabolites are released slowly into the bloodstream over time. The peak effects usually occur 1-3 hours after ingestion and can last for 4-12 hours, depending on the dosage and individual metabolism.
Conclusion
In conclusion, THC edibles work by being ingested, metabolized in the liver, crossing the blood-brain barrier, and binding to cannabinoid receptors in the brain. The effects are long-lasting and potent due to the formation of 11-hydroxy-THC. Understanding how THC edibles work in the body can help users make informed decisions about consumption and dosage.
FAQs
Q: How long do THC edibles take to kick in?
A: THC edibles can take anywhere from 30 minutes to 2 hours to take effect, depending on individual metabolism and the food consumed with the edible.
Q: Are there any risks associated with consuming THC edibles?
A: Consuming too much THC can lead to unpleasant side effects such as anxiety, paranoia, and hallucinations. It’s important to start with a low dosage and wait for the effects to fully kick in before consuming more.
Q: Can THC edibles be detected in drug tests?
A: Yes, THC and its metabolites can be detected in drug tests, even days after consumption. It’s important to be aware of drug testing policies, especially in workplaces that conduct random drug screenings.
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